{"entity":{"id":"nct06197425","kind":"trial","name":"Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer","aka":["CIRCULATE PAC"],"tldr":"A phase 3 trial in colorectal cancer, run by Centre Hospitalier Universitaire Dijon, now recruiting.","summary":"Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06197425 by Centre Hospitalier Universitaire Dijon, with a registry enrolment figure of 1660 participants, started 2026-05-07 and due to reach its primary completion in 2032-05. Interventions recorded: \"FOLFIRI\" cures; Trifluridine cures; BIOLOGICAL ASSESSMENT; Questionnaires; Thoracic-abdomino-pelvic scan or MRI. Conditions listed: Colon or Upper Rectum Adenocarcinoma. Primary outcome: The time to recurrence (TTR). Colorectal eligibility wording from the registry: \"* Fully resected stage III or high-risk stage II colon or upper rectum adenocarcinoma previously treated by standard adjuvant chemotherapy or peri-operative chemotherapy (FOLFOX or CAPOX) for either 3 or 6 months based on local multidisciplinary meeting, and on TNCD recommendations\". Sites: France. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06197425","url":"https://clinicaltrials.gov/study/NCT06197425"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["mrd-testing"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06197425","phase":"3","setting":"Phase III Multicentric, Open-label, Randomized Study to Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer (PRODIGE 88)","sponsor":"Centre Hospitalier Universitaire Dijon","enrolled":1660,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06197425/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"mrd-testing","kind":"technology","name":"MRD / molecular residual disease testing","route":"/technologies/mrd-testing/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}