{"entity":{"id":"nct06224673","kind":"trial","name":"ARX788 in HER2-low advanced breast cancer","aka":["ARX788 for Treating Patients With HER2-low Locally Advanced Unresectable or Metastatic Breast Cancer"],"tldr":"This study tests ARX788, a drug attached to an antibody that binds HER2, in advanced breast cancer with low HER2 expression.","summary":"This study tests ARX788, a drug attached to an antibody that binds HER2, in advanced breast cancer with low HER2 expression.\n\nInterventional study registered as NCT06224673, sponsored by Laura Huppert, MD, BA. Registry phase: 2. Registry enrollment is 36 participants (estimated). Registry status checked October 10, 2026: recruiting. UCSF lists this study as open to eligible people; local availability and overall registry status are separate. See the registry for full eligibility and current sites.","status":"recruiting","asOf":"2026-10-10","links":[{"label":"ClinicalTrials.gov NCT06224673","url":"https://clinicaltrials.gov/study/NCT06224673"},{"label":"UCSF study listing and local availability","url":"https://clinicaltrials.ucsf.edu/trial/NCT06224673"}],"tags":["ucsf-breast-coverage","interventional"],"related":[],"cancers":["breast-cancer","tnbc"],"sections":[],"technologies":[],"targets":[],"drugs":["arx788"],"companies":[],"institutions":["ucsf"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06224673","phase":"2","setting":"HER2-low unresectable or metastatic breast cancer","sponsor":"Laura Huppert, MD, BA","participation":[{"nct":"NCT06224673","source":"https://clinicaltrials.gov/study/NCT06224673","fetchedAt":"2026-10-10T20:54:18.251381Z","studySha256":"2431de014aae8966c182c390714ed1ff1defc6698bdf46685dc2a5ab73a4b597","overallStatus":"RECRUITING","lastUpdatePosted":"2026-06-11","leadSponsor":"Laura Huppert, MD, BA","collaboratorCount":1,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":36,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["United States"]}],"started":"2026-06-05","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06224673/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"drug":[{"id":"arx788","kind":"drug","name":"ARX788","route":"/drugs/arx788/"}],"institution":[{"id":"ucsf","kind":"institution","name":"UCSF Helen Diller Family Comprehensive Cancer Center","route":"/institutions/ucsf/"}]}}