{"entity":{"id":"nct06227065","kind":"trial","name":"Precise Chemoresection in Low-grade NMIBC Using Drug Screens in Patient-derived Organoids","aka":[],"tldr":"A phase 2 trial of Patient-derived organoids in Non-muscle-invasive bladder cancer, run by Hospital Centre Biel/Bienne, not yet recruiting.","summary":"Precise Chemoresection in Low-grade NMIBC Using Drug Screens in Patient-derived Organoids is a phase 2 interventional study registered as NCT06227065 by Hospital Centre Biel/Bienne, with 28 participants planned, started 2026-12-01 and due to reach its primary completion in 2030-11-30. Interventions recorded: Epirubicin, Mitomycin, Gemcitabine, Docetaxel. Conditions recorded: Bladder Cancer, Non-muscle Invasive Bladder Cancer, Low Grade.\n\nLinked to the technology Patient-derived organoids because the registry's title names it (\"patient derived organoids\") and Non-muscle-invasive bladder cancer among its conditions. Registry record only: no result has been read by an editor.","status":"planned","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT06227065","url":"https://clinicaltrials.gov/study/NCT06227065"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["non-muscle-invasive-bladder-cancer"],"sections":[],"technologies":["organoids"],"targets":[],"drugs":["epirubicin","gemcitabine","docetaxel"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06227065","phase":"2","setting":"POLO-Trial. Precise Neoadjuvant Chemoresection of Low-grade NMIBC Guided by Drug Sceens in Patient-derived Or-ganoids. An Open-label, Phase II Trial.","sponsor":"Hospital Centre Biel/Bienne","enrolled":28,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06227065/","neighbours":{"cancer":[{"id":"non-muscle-invasive-bladder-cancer","kind":"cancer","name":"Non-muscle-invasive bladder cancer","route":"/cancers/non-muscle-invasive-bladder-cancer/"}],"technology":[{"id":"organoids","kind":"technology","name":"Patient-derived organoids","route":"/technologies/organoids/"}],"drug":[{"id":"docetaxel","kind":"drug","name":"Docetaxel","route":"/drugs/docetaxel/"},{"id":"epirubicin","kind":"drug","name":"Epirubicin","route":"/drugs/epirubicin/"},{"id":"gemcitabine","kind":"drug","name":"Gemcitabine","route":"/drugs/gemcitabine/"}]}}