{"entity":{"id":"nct06232408","kind":"trial","name":"LIONS (PLK4 Inhibitor in Advanced Solid Tumors)","aka":[],"tldr":"A phase 1 trial of RP-1664 run by Repare Therapeutics, terminated.","summary":"LIONS (PLK4 Inhibitor in Advanced Solid Tumors) is a phase 1 interventional study registered as NCT06232408 by Repare Therapeutics, with 29 participants enrolled, started 2024-02-14. Conditions recorded: Advanced Solid Tumor. Interventions recorded: RP-1664.","status":"historic","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06232408","url":"https://clinicaltrials.gov/study/NCT06232408"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["rp-1664"],"companies":["repare-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06232408","phase":"1","setting":"Phase 1 Trial of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Clinical Activity of RP-1664 in Participants With Advanced Solid Tumors","sponsor":"Repare Therapeutics","enrolled":29,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06232408/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"rp-1664","kind":"drug","name":"RP-1664","route":"/drugs/rp-1664/"}],"company":[{"id":"repare-therapeutics","kind":"company","name":"Repare Therapeutics","route":"/companies/repare-therapeutics/"}]}}