{"entity":{"id":"nct06246344","kind":"trial","name":"Adaptive Boost Radiotherapy to Primary Lesions and Positive Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer","aka":[],"tldr":"A phase 3 trial of Adaptive radiotherapy in Rectal cancer, run by Shandong Cancer Hospital and Institute, active and no longer recruiting.","summary":"Adaptive Boost Radiotherapy to Primary Lesions and Positive Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer is a phase 3 interventional study registered as NCT06246344 by Shandong Cancer Hospital and Institute, with 128 participants planned, started 2023-12-01 and due to reach its primary completion in 2025-12-01. Interventions recorded: Online Adaptive Radiotherapy With Sequential Boost, Conventional Non-Adaptive IMRT, Capecitabine, CAPEOX, Total Mesorectal Excision. Conditions recorded: Rectal Cancer.\n\nLinked to the technology Adaptive radiotherapy because the registry names it (\"adaptive radiotherapy\") among its interventions and Rectal cancer among its conditions. Registry record only: no result has been read by an editor.","status":"active","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT06246344","url":"https://clinicaltrials.gov/study/NCT06246344"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["adaptive-radiotherapy"],"targets":[],"drugs":["capecitabine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06246344","phase":"3","setting":"Online Adaptive Radiotherapy With a Boost to the Primary Tumor and Clinically Involved Lymph Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer: A Prospective, Randomized Controlled Trial","sponsor":"Shandong Cancer Hospital and Institute","enrolled":128,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06246344/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"adaptive-radiotherapy","kind":"technology","name":"Adaptive radiotherapy (online replanning)","route":"/technologies/adaptive-radiotherapy/"}],"drug":[{"id":"capecitabine","kind":"drug","name":"Capecitabine","route":"/drugs/capecitabine/"}]}}