{"entity":{"id":"nct06293014","kind":"trial","name":"TAS-102 Combined With Bevacizumab for Second-line Maintenance Treatment of Advanced Colorectal Cancer","aka":[],"tldr":"A phase 2 trial of trifluridine/tipiracil and bevacizumab (glioblastoma use) in colorectal cancer, run by Henan Cancer Hospital, now recruiting.","summary":"TAS-102 Combined With Bevacizumab for Second-line Maintenance Treatment of Advanced Colorectal Cancer is a phase 2, randomised interventional study registered as NCT06293014 by Henan Cancer Hospital, with a registry enrolment figure of 224 participants, started 2024-02-23 and due to reach its primary completion in 2025-10-15. Interventions recorded: TAS-102+bevacizumab; Standard chemotherapy+bevacizumab. Conditions listed: Colorectal Cancer. Primary outcome: Time to treatment failure (TTF). Colorectal eligibility wording from the registry: \"Unresectable colorectal adenocarcinoma confirmed by histopathology or cytology;\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06293014","url":"https://clinicaltrials.gov/study/NCT06293014"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy"],"targets":[],"drugs":["trifluridine-tipiracil","bevacizumab-glioma"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06293014","phase":"2","setting":"A Randomized, Open-label, Multicentre Clinical Study of TAS-102 Combined With Bevacizumab for Second-line Maintenance Treatment of Advanced Colorectal Cancer","sponsor":"Henan Cancer Hospital","enrolled":224,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06293014/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"}],"drug":[{"id":"bevacizumab-glioma","kind":"drug","name":"Bevacizumab (glioblastoma use)","route":"/drugs/bevacizumab-glioma/"},{"id":"trifluridine-tipiracil","kind":"drug","name":"Trifluridine/tipiracil","route":"/drugs/trifluridine-tipiracil/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}