{"entity":{"id":"nct06300463","kind":"trial","name":"Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases","aka":[],"tldr":"A phase 2 trial of botensilimab and balstilimab in colorectal cancer, run by Weill Medical College of Cornell University, now recruiting.","summary":"Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases is a phase 2, randomised interventional study registered as NCT06300463 by Weill Medical College of Cornell University, with a registry enrolment figure of 24 participants, started 2024-03-26 and due to reach its primary completion in 2026-12. Interventions recorded: Botensilimab; Balstilimab; AGEN1423; Radiation. Conditions listed: Colorectal Cancer Metastatic; Liver Metastases; Colorectal Cancer. Primary outcome: Mean CD8:Treg ratio, as determined by flow cytometry of tumor tissue, at time of surgical resection in each treatment arm. Colorectal eligibility wording from the registry: \"* Diagnosis of metastatic colorectal adenocarcinoma with liver metastases\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06300463","url":"https://clinicaltrials.gov/study/NCT06300463"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["botensilimab","balstilimab"],"companies":["agenus"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06300463","phase":"2","setting":"Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases","sponsor":"Weill Medical College of Cornell University","enrolled":24,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06300463/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"balstilimab","kind":"drug","name":"Balstilimab","route":"/drugs/balstilimab/"},{"id":"botensilimab","kind":"drug","name":"Botensilimab","route":"/drugs/botensilimab/"}],"company":[{"id":"agenus","kind":"company","name":"Agenus","route":"/companies/agenus/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}