{"entity":{"id":"nct06315010","kind":"trial","name":"Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis","aka":["REPOSE"],"tldr":"A phase 2 trial of repotrectinib in lung cancer, run by MedSIR, now recruiting.","summary":"Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis is a phase 2, interventional study registered as NCT06315010 by MedSIR, with a registry enrolment figure of 20 participants, started 2025-06-27 and due to reach its primary completion in 2027-03. Interventions recorded: Repotrectinib. Conditions listed: NSCLC; Brain Metastases; ROS1 Gene Rearrangement. Primary outcome: Intracranial Objective Response Rate (IC-ORR). Lung eligibility wording from the registry: \"Histologically documented NSCLC\". Sites: Austria, Germany, Spain. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT06315010","url":"https://clinicaltrials.gov/study/NCT06315010"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["ros1-positive-nsclc"],"sections":[],"technologies":["kinase-inhibitors"],"targets":[],"drugs":["repotrectinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06315010","phase":"2","setting":"A Phase II Study Assessing Safety and Efficacy of Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis (The REPOSE Study)","sponsor":"MedSIR","enrolled":20,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06315010/","neighbours":{"cancer":[{"id":"ros1-positive-nsclc","kind":"cancer","name":"ROS1-positive non-small-cell lung cancer","route":"/cancers/ros1-positive-nsclc/"}],"technology":[{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"drug":[{"id":"repotrectinib","kind":"drug","name":"Repotrectinib","route":"/drugs/repotrectinib/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}