{"entity":{"id":"nct06321081","kind":"trial","name":"ICE Study: Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Beijing Hospital, now recruiting.","summary":"ICE Study: Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC is a phase 2, interventional study registered as NCT06321081 by Beijing Hospital, with a registry enrolment figure of 60 participants, started 2024-03-01 and due to reach its primary completion in 2026-12-30. Interventions recorded: irinotecan, cetuximab, envafolimab. Conditions listed: RAS Mutation; Metastatic Colorectal Cancer; MSS. Primary outcome: progression free survival. Colorectal eligibility wording from the registry: \"Histologically proven diagnosis of colorectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06321081","url":"https://clinicaltrials.gov/study/NCT06321081"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06321081","phase":"2","setting":"ICE Study: a Clinical Study of the Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC","sponsor":"Beijing Hospital","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06321081/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}