{"entity":{"id":"nct06326411","kind":"trial","name":"A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors","aka":[],"tldr":"A phase 1 trial of NST-628 run by Nested Therapeutics, Inc, now recruiting.","summary":"A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors is a phase 1 interventional study registered as NCT06326411 by Nested Therapeutics, Inc, with 230 participants planned, started 2024-04-09. Conditions recorded: Oncology, MEK Mutation, RAF Gene Mutation, Ras (KRAS or NRAS) Gene Mutation, Melanoma, NSCLC, Glioma, Solid Tumor, Adult and MAPK Pathway Gene Mutation. Interventions recorded: NST-628.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06326411","url":"https://clinicaltrials.gov/study/NCT06326411"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","melanoma","nsclc","brain-tumours"],"sections":[],"technologies":[],"targets":[],"drugs":["nst-628"],"companies":["nested-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06326411","phase":"1","setting":"A Phase I, Open Label Single-arm Two-part Study to Investigate Safety, Pharmacokinetics, and Preliminary Efficacy of Pan-RAF/MEK Glue NST-628 Oral Tablets in Subject With Solid Tumors Harboring Genetic Alterations in the MAPK Pathway and With Other Solid Tumors","sponsor":"Nested Therapeutics, Inc","enrolled":230,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06326411/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"nst-628","kind":"drug","name":"NST-628","route":"/drugs/nst-628/"}],"company":[{"id":"nested-therapeutics","kind":"company","name":"Nested Therapeutics","route":"/companies/nested-therapeutics/"}]}}