{"entity":{"id":"nct06328738","kind":"trial","name":"ELVN-002 With Trastuzumab +/- Chemotherapy in HER2+ Solid Tumors, Colorectal and Breast Cancer","aka":[],"tldr":"A phase 1 trial of ELVN-002 run by Enliven Therapeutics, active and no longer recruiting.","summary":"ELVN-002 With Trastuzumab +/- Chemotherapy in HER2+ Solid Tumors, Colorectal and Breast Cancer is a phase 1 interventional study registered as NCT06328738 by Enliven Therapeutics, with 275 participants planned, started 2024-05-30. Conditions recorded: HER2-positive Breast Cancer, HER2-positive Gastric Cancer, HER2 Positive Solid Tumors, HER2 Amplification and Colorectal Cancer. Interventions recorded: ELVN-002, Trastuzumab, 5-Fluorouracil, Oxaliplatin, Capecitabine, Eribulin, paclitaxel and Leucovorin.","status":"active","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06328738","url":"https://clinicaltrials.gov/study/NCT06328738"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["breast-her2-positive","gastric-her2-positive","metastatic-cancer","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["elvn-002"],"companies":["enliven-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06328738","phase":"1","setting":"A Phase 1a/1b Study of ELVN-002 Combined With Trastuzumab in Advanced Stage HER2+ Solid Tumors, and ELVN-002 Combined With Trastuzumab and Chemotherapy in Advanced Stage HER2+ Colorectal Cancer and Breast Cancer","sponsor":"Enliven Therapeutics","enrolled":275,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06328738/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"gastric-her2-positive","kind":"cancer","name":"HER2-positive gastric cancer","route":"/cancers/gastric-her2-positive/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"elvn-002","kind":"drug","name":"ELVN-002","route":"/drugs/elvn-002/"}],"company":[{"id":"enliven-therapeutics","kind":"company","name":"Enliven Therapeutics","route":"/companies/enliven-therapeutics/"}]}}