{"entity":{"id":"nct06343116","kind":"trial","name":"Nimotuzumab Combined With Trifluridine/Tipiracil in the Treatment of Refractory Metastatic Colorectal Cancer","aka":["NOTABLE-308"],"tldr":"A phase 3 trial of trifluridine/tipiracil in colorectal cancer, run by Biotech Pharmaceutical Co., Ltd., not yet recruiting.","summary":"Nimotuzumab Combined With Trifluridine/Tipiracil in the Treatment of Refractory Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06343116 by Biotech Pharmaceutical Co., Ltd., with a registry enrolment figure of 420 participants, started 2024-04 and due to reach its primary completion in 2027-04. Interventions recorded: Nimotuzumab injection; Placebo; Trifluridine/tipiracil. Conditions listed: Refractory Metastatic Colorectal Cancer. Primary outcome: overall survival (OS); dose-limiting toxicity (DLT). Colorectal eligibility wording from the registry: \"Histologically or cytologically confirmed diagnosis of colorectal cancer (CRC);\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06343116","url":"https://clinicaltrials.gov/study/NCT06343116"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy"],"targets":[],"drugs":["trifluridine-tipiracil"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06343116","phase":"3","setting":"Randomized Double-blind, Placebo-controlled, Multicenter Clinical Study of Nimotuzumab Combined With Trifluridine/Tipiracil in Third-line and Beyond for the Treatment of Metastatic Colorectal Cancer","sponsor":"Biotech Pharmaceutical Co., Ltd.","enrolled":420,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06343116/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"}],"drug":[{"id":"trifluridine-tipiracil","kind":"drug","name":"Trifluridine/tipiracil","route":"/drugs/trifluridine-tipiracil/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}