{"entity":{"id":"nct06356584","kind":"trial","name":"Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Shandong Cancer Hospital and Institute, now recruiting.","summary":"Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases is a phase 2, randomised interventional study registered as NCT06356584 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 62 participants, started 2024-04-01 and due to reach its primary completion in 2026-10-01. Interventions recorded: Immunotherapy (Sintilimab); Targeted Therapy Agent (Fruquintinib); Radiotherapy (SBRT and LDRT). Conditions listed: Colorectal Cancer; Immunotherapy; Radiotherapy; Targeted Therapy; Liver Metastasis. Primary outcome: Progression-free survival (PFS). Colorectal eligibility wording from the registry: \"* Histologically confirmed colorectal adenocarcinoma with liver metastases (8th edition AJCC)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06356584","url":"https://clinicaltrials.gov/study/NCT06356584"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06356584","phase":"2","setting":"Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases: A Randomized, Controlled, Multicenter Phase II Trial","sponsor":"Shandong Cancer Hospital and Institute","enrolled":62,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06356584/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}