{"entity":{"id":"nct06380816","kind":"trial","name":"A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer","aka":[],"tldr":"A phase 1/2 trial in triple-negative breast cancer, run by Cancer Research UK, now recruiting.","summary":"A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer is a phase 1/2, interventional study registered as NCT06380816 by Cancer Research UK, with a registry enrolment figure of 167 participants, started 2024-07-09 and due to reach its primary completion in 2029-11. Interventions recorded: UCB4594. Conditions listed: Advanced Solid Tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Renal Cell (Clear Cell Only); Esophageal Neoplasms; Stomach Neoplasms (Excluding Gastrointestinal Stromal Tumors); Uterine Cervical Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms. Triple-negative eligibility wording from the registry: \"Module A (dose escalation): Tumour types which have shown high levels of human HLA-G expression (as reported in the literature): head and neck squamous cell carcinoma, non-small cell lung cancer, colorectal cancer, triple-negative breast cancer, renal cell cancer (clear cell only), oesophago-gastric\". Sites: United Kingdom. United Kingdom sites listed: 4. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06380816","url":"https://clinicaltrials.gov/study/NCT06380816"}],"tags":["ctgov-ingest","tnbc-deep-dive"],"related":[],"cancers":["tnbc-metastatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["UK sites (registry): Guy's Hopsital (London); The Christie NHS Foundation Trust (Manchester); The Newcastle upon Tyne Hospitals NHS Foundation Trust (Newcastle upon Tyne); University Hospital Southampton NHS Foundation Trust (Southampton)."],"nct":"NCT06380816","phase":"1/2","setting":"A Cancer Research UK Phase I/II Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of UCB4594 Alone and in Combination With Anti-cancer Treatments in Participants With Advanced Malignancies","sponsor":"Cancer Research UK","enrolled":167,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06380816/","neighbours":{"cancer":[{"id":"tnbc-metastatic","kind":"cancer","name":"Metastatic triple-negative breast cancer","route":"/cancers/tnbc-metastatic/"}],"term":[{"id":"tnbc-trials-open-today","kind":"term","name":"Triple-negative breast cancer trials open today (registry snapshot and UK sites)","route":"/terms/tnbc-trials-open-today/"}]}}