{"entity":{"id":"nct06385678","kind":"trial","name":"A Study of HRS-4642 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation","aka":[],"tldr":"A phase 1/2 trial of Adebrelimab, Carboplatin, Cisplatin, Pemetrexed and Cetuximab in advanced solid tumours, run by Jiangsu HengRui Medicine Co., Ltd., active and no longer recruiting.","summary":"A Study of HRS-4642 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation is a phase 1/2 interventional study registered as NCT06385678 by Jiangsu HengRui Medicine Co., Ltd., with 47 participants enrolled, started 2024-07-05 and due to reach its primary completion in 2025-12. Interventions recorded: HRS-4642, Adebrelimab, SHR-9839, Pemetrexed Disodium for Injection、Cisplatin Injection、Carboplatin for Injection and Cetuximab Solution for Infusion.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT06385678","url":"https://clinicaltrials.gov/study/NCT06385678"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["adebrelimab","carboplatin","cisplatin","pemetrexed","cetuximab"],"companies":["hengrui"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT06385678","phase":"1/2","setting":"A Phase IB/II Clinical Study on the Safety, Tolerability and Efficacy of HRS-4642 in Combination With Anti-tumor Medication in Subjects With Advanced Solid Tumors","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","enrolled":47,"outcomes":[]},"route":"/trials/nct06385678/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"adebrelimab","kind":"drug","name":"Adebrelimab","route":"/drugs/adebrelimab/"},{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"cetuximab","kind":"drug","name":"Cetuximab","route":"/drugs/cetuximab/"},{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"pemetrexed","kind":"drug","name":"Pemetrexed","route":"/drugs/pemetrexed/"}],"company":[{"id":"hengrui","kind":"company","name":"Jiangsu Hengrui Pharmaceuticals","route":"/companies/hengrui/"}]}}