{"entity":{"id":"nct06391905","kind":"trial","name":"PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for the Treatment of Advanced Colorectal Cancer With pMMR/MSS","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Guangdong Provincial People's Hospital, not yet recruiting.","summary":"PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for the Treatment of Advanced Colorectal Cancer With pMMR/MSS is a phase 2, randomised interventional study registered as NCT06391905 by Guangdong Provincial People's Hospital, with a registry enrolment figure of 60 participants, started 2024-05-06 and due to reach its primary completion in 2028-04-06. Interventions recorded: PCSK9 inhibitor in combination with standard advanced first-line regimen group; standard advanced first-line regimen group. Conditions listed: Colorectal Cancer. Primary outcome: Objective response rateObjective response rate (ORR). Colorectal eligibility wording from the registry: \"Histologically confirmed colorectal adenocarcinoma with pMMR/MSS;\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06391905","url":"https://clinicaltrials.gov/study/NCT06391905"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06391905","phase":"2","setting":"PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for the Treatment of Advanced Colorectal Cancer With pMMR/MSS","sponsor":"Guangdong Provincial People's Hospital","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06391905/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}