{"entity":{"id":"nct06419634","kind":"trial","name":"Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome","aka":[],"tldr":"A phase 1 trial of ORM-6151 (BMS-986497) run by Bristol-Myers Squibb, terminated.","summary":"Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome is a phase 1 interventional study registered as NCT06419634 by Bristol-Myers Squibb, with 34 participants enrolled, started 2024-05-29. Conditions recorded: Acute Myeloid Leukemia and Myelodysplastic Syndrome. Interventions recorded: BMS-986497, Azacitidine and Venetoclax.","status":"historic","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06419634","url":"https://clinicaltrials.gov/study/NCT06419634"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["aml","mds"],"sections":[],"technologies":[],"targets":[],"drugs":["orm-6151"],"companies":["orum-therapeutics","bms"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06419634","phase":"1","setting":"Phase I Multicenter, Open-Label, First-in-Human Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double Combination With Azacitidine and in Triple Combination With Azacitidine and Venetoclax in Subjects With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome","sponsor":"Bristol-Myers Squibb","enrolled":34,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06419634/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}],"drug":[{"id":"orm-6151","kind":"drug","name":"ORM-6151 (BMS-986497)","route":"/drugs/orm-6151/"}],"company":[{"id":"bms","kind":"company","name":"Bristol Myers Squibb","route":"/companies/bms/"},{"id":"orum-therapeutics","kind":"company","name":"Orum Therapeutics","route":"/companies/orum-therapeutics/"}]}}