{"entity":{"id":"nct06446557","kind":"trial","name":"De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unrese","aka":["DIAMOND"],"tldr":"A phase 3 trial in colorectal cancer, run by University Hospital, Rouen, not yet recruiting.","summary":"De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06446557 by University Hospital, Rouen, with a registry enrolment figure of 408 participants, started 2026-06 and due to reach its primary completion in 2032-06-01. Interventions recorded: treatment adaptation guided by ctDNA variation; standard management. Conditions listed: Metastatic Colon Cancer. Primary outcome: Evaluate the superiority in quality-adjusted OS of an early treatment adaptation guided by ctDNA variation. Colorectal eligibility wording from the registry: \"* Histologically proven diagnosis of RAS WT or mutant, MSS, BRAFV600E non-mutated colorectal cancer\". Sites: France. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06446557","url":"https://clinicaltrials.gov/study/NCT06446557"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":["mrd-testing"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06446557","phase":"3","setting":"De-scalation or swItch of Treatment According to Circulating tuMOr DNA Variation After 2 Cycles of Doublet Chemotherapy Plus Targeted Agent in Metastatic Unresectable Colorectal Cancer (DIAMOND Study): A Randomized Phase III of PRODIGE Intergroup","sponsor":"University Hospital, Rouen","enrolled":408,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06446557/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"technology":[{"id":"mrd-testing","kind":"technology","name":"MRD / molecular residual disease testing","route":"/technologies/mrd-testing/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}