{"entity":{"id":"nct06454890","kind":"trial","name":"Clinical Study of Trop2 CAR-NK in the Treatment of Relapsed/Refractory Non-Small Cell Lung Cancer (NSCLC)","aka":[],"tldr":"This study tests TROP-2-directed treatment; the registry reports that it is not yet recruiting.","summary":"The registry lists NCT06454890 as not yet recruiting, last updated 2024-06-12. Enrolment is 50 planned participants, an estimate. Interventions: Anti-Trop2 CAR-NK cell. Primary measures include Safety by Common Terminology Criteria for Adverse Events (CTCAE) V5.0; Objective Response Rate (ORR). No results are posted in the registry; this does not exclude separate publications.","status":"planned","asOf":"2026-10-06","links":[{"label":"ClinicalTrials.gov NCT06454890","url":"https://clinicaltrials.gov/study/NCT06454890"}],"tags":[],"related":[],"cancers":["nsclc","sclc"],"sections":[],"technologies":[],"targets":["trop2"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06454890","phase":"1/2","setting":"An Investigator-initiated Trial Evaluating the Efficacy and Safety of Anti-Trop2 Universal CAR-NK(U-CAR-NK) Cells Therapy Combined With Chemotherapy for Relapsed/Refractory Non-Small Cell Lung Cancer (NSCLC)","sponsor":"Henan Cancer Hospital","started":"2024-08-01","startedType":"estimated","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06454890/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}]}}