{"entity":{"id":"nct06457906","kind":"trial","name":"SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC","aka":["SHARP"],"tldr":"A phase 3 trial in lung cancer, run by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, now recruiting.","summary":"SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC is a phase 3, randomised interventional study registered as NCT06457906 by Cancer Institute and Hospital, Chinese Academy of Medical Sciences, with a registry enrolment figure of 340 participants, started 2023-09-01 and due to reach its primary completion in 2027-08-30. Interventions recorded: Experimental group (SRS/SRT/Hypo-RT); Controled group (HA-WBRT). Conditions listed: Small-cell Lung Cancer; Brain Metastases; SRS; Stereotactic Radiotherapy; Whole Brain Radiotherpay; Hippocampal-avoidance. Primary outcome: Cognitive function scores; Meadian OS time. Lung eligibility wording from the registry: \"Pathologically (histologically or cytologically) proven diagnosis of small cell lung cancer within 5 years of registration\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT06457906","url":"https://clinicaltrials.gov/study/NCT06457906"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["sclc"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06457906","phase":"3","setting":"SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in Patients With Small-Cell Lung Cancer: A Prospective, Randomized, Multicenter Phase III Trial (SHARP Trial)","sponsor":"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","enrolled":340,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06457906/","neighbours":{"cancer":[{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}