{"entity":{"id":"nct06500455","kind":"trial","name":"Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain","aka":[],"tldr":"A phase 3 trial in lung cancer, run by NRG Oncology, active but no longer recruiting.","summary":"Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain is a phase 3, randomised interventional study registered as NCT06500455 by NRG Oncology, with a registry enrolment figure of 274 participants, started 2024-12-12 and due to reach its primary completion in 2028-06-30. Interventions recorded: Computed Tomography; Fractionated Stereotactic Radiation Therapy; Magnetic Resonance Imaging; Stereotactic Radiosurgery. Conditions listed: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Metastatic Digestive System Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Solid Neoplasm; Metastatic Melanom. Primary outcome: Time to local failure. Lung eligibility wording from the registry: \"* Non-small cell lung cancer\". Sites: Canada, Hong Kong, Ireland, United States. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT06500455","url":"https://clinicaltrials.gov/study/NCT06500455"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06500455","phase":"3","setting":"Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases","sponsor":"NRG Oncology","enrolled":274,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06500455/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}