{"entity":{"id":"nct06500481","kind":"trial","name":"Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial","aka":[],"tldr":"A phase 3 trial in lung cancer, run by NRG Oncology, now recruiting.","summary":"Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial is a phase 3, randomised interventional study registered as NCT06500481 by NRG Oncology, with a registry enrolment figure of 115 participants, started 2025-03-04 and due to reach its primary completion in 2028-07-31. Interventions recorded: Biospecimen Collection; Computed Tomography; Involved-Field Radiation Therapy; Lumbar Puncture; Magnetic Resonance Imaging; Positron Emission Tomography; Proton Beam Craniospinal Irradiation; Quality-of-Life Assessment. Conditions listed: Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Neoplasm in the Leptomeninges; Stage IV Lung Cancer AJCC v8. Primary outcome: Overall survival (OS). Lung eligibility wording from the registry: \"* Patients with pathologically (histologically or cytologically) proven diagnosis of breast cancer or NSCLC\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT06500481","url":"https://clinicaltrials.gov/study/NCT06500481"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["imrt-igrt","proton-therapy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06500481","phase":"3","setting":"A Phase III Randomized Clinical Trial of Proton Craniospinal Irradiation Versus Involved-Field Radiotherapy for Patients With Breast Cancer or Non-Small Cell Lung Cancer Leptomeningeal Metastasis (Radiate-LM)","sponsor":"NRG Oncology","enrolled":115,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06500481/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}