{"entity":{"id":"nct06525428","kind":"trial","name":"Standard Systemic Therapy Combined With High/Low-dose Radiotherapy Plus Toripalimab for Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 2 trial of toripalimab in colorectal cancer, run by Fudan University, now recruiting.","summary":"Standard Systemic Therapy Combined With High/Low-dose Radiotherapy Plus Toripalimab for Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT06525428 by Fudan University, with a registry enrolment figure of 96 participants, started 2024-04-01 and due to reach its primary completion in 2026-12. Interventions recorded: standard systemic therapy combined with high/low-dose radiotherapy plus toripalimab. Conditions listed: Microsatellite Stable Metastatic Colorectal Cancer. Primary outcome: PFS. Colorectal eligibility wording from the registry: \"Histopathological confirmed MSS/pMMR adenocarcinoma of the colon or rectum\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06525428","url":"https://clinicaltrials.gov/study/NCT06525428"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor","imrt-igrt"],"targets":[],"drugs":["toripalimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06525428","phase":"2","setting":"A Prospective, Two-cohort Phase II Trial of Standard Systemic Therapy in Combination With High/Low-dose Radiotherapy Plus Toripalimab for Metastatic Colorectal Cancer","sponsor":"Fudan University","enrolled":96,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06525428/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"toripalimab","kind":"drug","name":"Toripalimab","route":"/drugs/toripalimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}