{"entity":{"id":"nct06533761","kind":"trial","name":"Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML/HR-MDS and in Combination With Azacitidine in Previously Untreated HR-MDS","aka":[],"tldr":"A phase 1 trial of Eganelisib run by Stelexis BioSciences, now recruiting.","summary":"Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML/HR-MDS and in Combination With Azacitidine in Previously Untreated HR-MDS is a phase 1 interventional study registered as NCT06533761 by Stelexis BioSciences, with 105 participants planned, started 2025-04-28. Conditions recorded: AML, Adult and MDS. Interventions recorded: Eganelisib, Eganelisib in combination with cytarabine, Eganelisib in combination with azacitidine and Azacitadine (AZA).","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06533761","url":"https://clinicaltrials.gov/study/NCT06533761"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["aml","mds"],"sections":[],"technologies":[],"targets":[],"drugs":["eganelisib"],"companies":["stelexis-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06533761","phase":"1","setting":"A Phase 1b Open-Label Study to Evaluate the Safety and Tolerability of Eganelisib as Monotherapy and in Combination With Cytarabine in Patients With Relapsed/Refractory Acute Myeloid Leukemia or Higher Risk Myelodysplastic Syndrome and Eganelisib in Combination With Azacitidine in PI3K-Gamma-Positive Patients With Previously Untreated Higher Risk Myelodysplastic Syndrome","sponsor":"Stelexis BioSciences","enrolled":105,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06533761/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}],"drug":[{"id":"eganelisib","kind":"drug","name":"Eganelisib","route":"/drugs/eganelisib/"}],"company":[{"id":"stelexis-biosciences","kind":"company","name":"Stelexis BioSciences","route":"/companies/stelexis-biosciences/"}]}}