{"entity":{"id":"nct06545747","kind":"trial","name":"Adaptive Hypofractionated Radiotherapy for Locally Advanced NSCLC Based on Dynamic Enhanced MRI","aka":[],"tldr":"A phase 3 trial in lung cancer, run by Sun Yat-sen University, now recruiting.","summary":"Adaptive Hypofractionated Radiotherapy for Locally Advanced NSCLC Based on Dynamic Enhanced MRI is a phase 3, randomised interventional study registered as NCT06545747 by Sun Yat-sen University, with a registry enrolment figure of 490 participants, started 2024-08-01 and due to reach its primary completion in 2028-07-31. Interventions recorded: DCE-MRI based split-course hypo-RT; CT based split-course hypo-RT; Concurrent chemotherapy; Consolidative immunotherapy. Conditions listed: Non-small Cell Lung Cancer. Primary outcome: treatment-related G2+ respiratory toxicity; progression-free survival rate. Lung eligibility wording from the registry: \"* Patients must have histological or cytological confirmation of locally advanced, unresectable (stage III) non-small cell lung cancer (NSCLC)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT06545747","url":"https://clinicaltrials.gov/study/NCT06545747"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["stage-iii-unresectable-nsclc"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06545747","phase":"3","setting":"A Randomized Controlled Phase III Study of Adaptive Hypofractionated Radiotherapy Combined With Concurrent Chemotherapy and Consolidative Immunotherapy in Locally Advanced Non-Small Cell Lung Cancer Based on Dynamic Enhanced Magnetic Resonance Imaging","sponsor":"Sun Yat-sen University","enrolled":490,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06545747/","neighbours":{"cancer":[{"id":"stage-iii-unresectable-nsclc","kind":"cancer","name":"Unresectable stage III non-small-cell lung cancer","route":"/cancers/stage-iii-unresectable-nsclc/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}