{"entity":{"id":"nct06557733","kind":"trial","name":"An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by National Cancer Institute (NCI), now recruiting.","summary":"An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis is a phase 2, interventional study registered as NCT06557733 by National Cancer Institute (NCI), with a registry enrolment figure of 38 participants, started 2026-03-31 and due to reach its primary completion in 2027-06-30. Interventions recorded: Biopsy Procedure; Biospecimen Collection; EP2/EP4 Antagonist TPST-1495; Esophagogastroduodenoscopy; Gastrointestinal Endoscopy; Questionnaire Administration. Conditions listed: Colorectal Carcinoma; Familial Adenomatous Polyposis. Primary outcome: Percent change in duodenal polyp burden; Incidence of adverse events. Colorectal eligibility wording from the registry: \"* Clinical diagnosis of classic FAP with ≥ 100 colorectal adenomas status post colectomy or a sub-total colectomy and a family history of FAP\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06557733","url":"https://clinicaltrials.gov/study/NCT06557733"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06557733","phase":"2","setting":"Phase 2 Study to Evaluate the Efficacy and Safety of TPST-1495 in Patients With Familial Adenomatous Polyposis (FAP)","sponsor":"National Cancer Institute (NCI)","enrolled":38,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06557733/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}