{"entity":{"id":"nct06563986","kind":"trial","name":"FTD-TPI, Bevacizumab, and Radioembolization With 166Ho-microspheres in Refractory Metastatic Colorectal Cancer","aka":["STARLIGHT"],"tldr":"A phase 2 trial of bevacizumab (glioblastoma use) in colorectal cancer, run by UMC Utrecht, now recruiting.","summary":"FTD-TPI, Bevacizumab, and Radioembolization With 166Ho-microspheres in Refractory Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT06563986 by UMC Utrecht, with a registry enrolment figure of 40 participants, started 2024-06-18 and due to reach its primary completion in 2028-01. Interventions recorded: Systemic treatment (FTD-TPI and bevacizumab); Radioembolization with 166-Ho microspheres. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Hepatic objective response rate (hORR) (PERCIST 1.0). Colorectal eligibility wording from the registry: \"* Prior therapy with fluoropyrimidine, oxaliplatin, and irinotecan for the treatment of metastatic colorectal cancer and had demonstrated progressive disease or intolerance to their last regimen\". Sites: Netherlands. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06563986","url":"https://clinicaltrials.gov/study/NCT06563986"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["bevacizumab-glioma"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06563986","phase":"2","setting":"Single-arm, Phase II Trial of Trifluridine/Tipiracil (FTD-TPI), Bevacizumab, and Individualized Radioembolization With 166Ho-microspheres in Refractory Metastatic Colorectal Cancer","sponsor":"UMC Utrecht","enrolled":40,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06563986/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"bevacizumab-glioma","kind":"drug","name":"Bevacizumab (glioblastoma use)","route":"/drugs/bevacizumab-glioma/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}