{"entity":{"id":"nct06577987","kind":"trial","name":"Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies","aka":[],"tldr":"A phase 1 trial of CID-078 run by Circle Pharma, active and no longer recruiting.","summary":"Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies is a phase 1 interventional study registered as NCT06577987 by Circle Pharma, with 220 participants planned, started 2024-08-14. Conditions recorded: Advanced Solid Tumor, Metastatic Solid Tumor, Refractory Solid Tumor, Cancer, Lung Cancer, Triple Negative Breast Cancer, Breast Neoplasms, Neuroendocrine Tumors, Neuroendocrine Carcinoma and RB1 Gene Mutation. Interventions recorded: CID-078 Monotherapy.","status":"active","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06577987","url":"https://clinicaltrials.gov/study/NCT06577987"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","lung-cancer","tnbc","breast-cancer","neuroendocrine","cervical-small-cell-neuroendocrine-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":["cid-078"],"companies":["circle-pharma"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06577987","phase":"1","setting":"A Phase 1, Open-Label, Multicenter Study to Evaluate the Safety and Efficacy of the Oral Cyclin A/B-RxL Inhibitor CID-078 in Patients With Advanced Solid Tumor Malignancies","sponsor":"Circle Pharma","enrolled":220,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06577987/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"cervical-small-cell-neuroendocrine-carcinoma","kind":"cancer","name":"Small cell neuroendocrine carcinoma of the cervix","route":"/cancers/cervical-small-cell-neuroendocrine-carcinoma/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"drug":[{"id":"cid-078","kind":"drug","name":"CID-078","route":"/drugs/cid-078/"}],"company":[{"id":"circle-pharma","kind":"company","name":"Circle Pharma","route":"/companies/circle-pharma/"}]}}