{"entity":{"id":"nct06580574","kind":"trial","name":"Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Peking University, now recruiting.","summary":"Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers is a phase 2, interventional study registered as NCT06580574 by Peking University, with a registry enrolment figure of 34 participants, started 2024-09-13 and due to reach its primary completion in 2029-06-01. Interventions recorded: PD1/PDL1 antibody monotherapy, up to 24 weeks; Intensive immunotherapy plus anti-VEGF treatment, up to 24 weeks; Radical surgery. Conditions listed: Gastric Cancer; Colon Cancer; MSI-H; DMMR Cancer. Primary outcome: Organ preservation rate. Colorectal eligibility wording from the registry: \"* Histologically confirmed gastric cancer or colon cancer, without distant metastasis based on CR or MR\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06580574","url":"https://clinicaltrials.gov/study/NCT06580574"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer","msi-high-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06580574","phase":"2","setting":"PD-1/PD-L1 Antibody With Selective Combination of Sintilimab, IBI310 and Lenvatinib Used for Organ Preservation in Non-metastatic Gastric or Colon Cancers With Mismatch Repair Deficiency or High Microsatellite Instability","sponsor":"Peking University","enrolled":34,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06580574/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}