{"entity":{"id":"nct06593548","kind":"trial","name":"Lvosidenib (AK112) Combined With CapeOX and Radiotherapy in Patients With Unresectable Metastatic MSS-type Colorectal Cancer","aka":[],"tldr":"A phase 2 trial of ivosidenib in colorectal cancer, run by Fudan University, not yet recruiting.","summary":"Lvosidenib (AK112) Combined With CapeOX and Radiotherapy in Patients With Unresectable Metastatic MSS-type Colorectal Cancer is a phase 2, interventional study registered as NCT06593548 by Fudan University, with a registry enrolment figure of 36 participants, started 2024-11-01 and due to reach its primary completion in 2026-11-01. Interventions recorded: Ivosidenib (AK112). Conditions listed: CRC; MSS; Metastatic Cancer. Primary outcome: PFS. Colorectal eligibility wording from the registry: \"* Initial diagnosis confirmed by colonoscopy and pathology as colorectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06593548","url":"https://clinicaltrials.gov/study/NCT06593548"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":["ivosidenib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06593548","phase":"2","setting":"A Prospective, Single-arm, Single-center, Phase II Clinical Study of Ivosidenib (AK112) Combined With CapeOX and Radiotherapy in Patients With Unresectable Metastatic MSS-type Colorectal Cancer: Efficacy and Safety Assessment","sponsor":"Fudan University","enrolled":36,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06593548/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"ivosidenib","kind":"drug","name":"Ivosidenib","route":"/drugs/ivosidenib/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}