{"entity":{"id":"nct06599827","kind":"trial","name":"Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk LARC","aka":["iMHRT-LARC"],"tldr":"A phase 2 trial in colorectal cancer, run by Shanghai Zhongshan Hospital, not yet recruiting.","summary":"Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk LARC is a phase 2, interventional study registered as NCT06599827 by Shanghai Zhongshan Hospital, with a registry enrolment figure of 54 participants, started 2024-09-20 and due to reach its primary completion in 2026-09-20. Interventions recorded: moderately hypofractionated radiotherapy; chemotherapy; immunotherapy; Total mesorectal excision (TME) surgery. Conditions listed: Rectal Cancer. Primary outcome: pathologic complete response (pCR). Colorectal eligibility wording from the registry: \"MRI-confirmed rectal adenocarcinoma with the lower edge of the lesion ≤10cm from the anal verge\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06599827","url":"https://clinicaltrials.gov/study/NCT06599827"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06599827","phase":"2","setting":"Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-risk PMMR/MSS Locally Advanced Rectal Cancer: a Prospective, Exploratory Phase II Trial（iMHRT-LARC）","sponsor":"Shanghai Zhongshan Hospital","enrolled":54,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06599827/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}