{"entity":{"id":"nct06614751","kind":"trial","name":"A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway","aka":[],"tldr":"A phase 1 trial of DAT-2645 run by Danatlas Pharmaceuticals Co., Ltd, not yet recruiting.","summary":"A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway is a phase 1 interventional study registered as NCT06614751 by Danatlas Pharmaceuticals Co., Ltd, with 112 participants planned, started 2024-11-01. Conditions recorded: Solid Cancers, BRCA Mutation, HRD Cancer, Breast Cancer, Prostate Cancer, Colorectal Cancer, Pancreatic Cancer, Endometrial Cancer, Gastric Cancer, Advanced Cancer and Metastatic Solid Tumors. Interventions recorded: DAT-2645 tablet and DAT-2645 tablet.","status":"planned","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06614751","url":"https://clinicaltrials.gov/study/NCT06614751"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","breast-cancer","prostate","colorectal","pancreatic","endometrial","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":["dat-2645"],"companies":["danatlas-pharmaceuticals"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06614751","phase":"1","setting":"A Phase I, Open-label, Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of DAT-2645 in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DNA Damage Repair Pathway","sponsor":"Danatlas Pharmaceuticals Co., Ltd","enrolled":112,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06614751/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"drug":[{"id":"dat-2645","kind":"drug","name":"DAT-2645","route":"/drugs/dat-2645/"}],"company":[{"id":"danatlas-pharmaceuticals","kind":"company","name":"Danatlas Pharmaceuticals","route":"/companies/danatlas-pharmaceuticals/"}]}}