{"entity":{"id":"nct06625515","kind":"trial","name":"First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers","aka":[],"tldr":"A phase 1 trial of ATX-559 run by Accent Therapeutics, terminated.","summary":"First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers is a phase 1 interventional study registered as NCT06625515 by Accent Therapeutics, with 17 participants enrolled, started 2024-10-11. Conditions recorded: Advanced Solid Tumors, Breast Cancer Recurrent, Colorectal Cancer Metastatic, Colon Cancer, Rectal Adenocarcinoma and Endometrial Cancer. Interventions recorded: ATX-559.","status":"historic","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06625515","url":"https://clinicaltrials.gov/study/NCT06625515"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","breast-cancer","colon-cancer","rectal-cancer","endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":["atx-559"],"companies":["accent-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06625515","phase":"1","setting":"A Phase 1/2, Open-Label, Dose-Escalation and Expansion First-In-Human Study of ATX-559, an Oral Inhibitor of the Helicase DHX9, in Patients With Locally Advanced or Metastatic Solid Tumors and Molecularly Defined Cancers","sponsor":"Accent Therapeutics","enrolled":17,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06625515/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"atx-559","kind":"drug","name":"ATX-559","route":"/drugs/atx-559/"}],"company":[{"id":"accent-therapeutics","kind":"company","name":"Accent Therapeutics","route":"/companies/accent-therapeutics/"}]}}