{"entity":{"id":"nct06638307","kind":"trial","name":"MEN2312 in advanced breast cancer","aka":["A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer"],"tldr":"This first human study tests MEN2312, a drug that blocks an enzyme involved in controlling gene activity. It studies safety, dose and early signs of activity in advanced breast cancer.","summary":"This first human study tests MEN2312, a drug that blocks an enzyme involved in controlling gene activity. It studies safety, dose and early signs of activity in advanced breast cancer.\n\nInterventional study registered as NCT06638307, sponsored by Stemline Therapeutics, Inc.. Registry phase: 1. Registry enrollment is 240 participants (estimated). Registry status checked October 10, 2026: recruiting. UCSF lists this study as open to eligible people; local availability and overall registry status are separate. See the registry for full eligibility and current sites.","status":"recruiting","asOf":"2026-10-10","links":[{"label":"ClinicalTrials.gov NCT06638307","url":"https://clinicaltrials.gov/study/NCT06638307"},{"label":"UCSF study listing and local availability","url":"https://clinicaltrials.ucsf.edu/trial/NCT06638307"}],"tags":["ucsf-breast-coverage","interventional"],"related":[],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["elacestrant"],"companies":[],"institutions":["ucsf"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06638307","phase":"1","setting":"Advanced breast cancer","sponsor":"Stemline Therapeutics, Inc.","participation":[{"nct":"NCT06638307","source":"https://clinicaltrials.gov/study/NCT06638307","fetchedAt":"2026-10-10T20:54:18.544462Z","studySha256":"88a956a7771da8f121bc8d443a95386f05ed8cfe51c413cf6f04049b67b99bce","overallStatus":"RECRUITING","lastUpdatePosted":"2026-08-07","leadSponsor":"Stemline Therapeutics, Inc.","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":240,"enrolmentType":"ESTIMATED","siteCount":45,"recruitingSiteCount":45,"countries":["Spain","United States"]}],"started":"2024-10-25","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06638307/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"drug":[{"id":"elacestrant","kind":"drug","name":"Elacestrant","route":"/drugs/elacestrant/"}],"institution":[{"id":"ucsf","kind":"institution","name":"UCSF Helen Diller Family Comprehensive Cancer Center","route":"/institutions/ucsf/"}]}}