{"entity":{"id":"nct06642844","kind":"trial","name":"Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment","aka":["PHARBEVACOL"],"tldr":"A phase 3 trial in colorectal cancer, run by University Hospital, Tours, now recruiting.","summary":"Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment is a phase 3, randomised interventional study registered as NCT06642844 by University Hospital, Tours, with a registry enrolment figure of 244 participants, started 2025-03-04 and due to reach its primary completion in 2028-03-04. Interventions recorded: Avastin, 25 Mg/mL Intravenous Solution. Conditions listed: Unresectable Metastatic Colorectal Cancer. Primary outcome: The primary endpoint is progression-free survival (PFS). Colorectal eligibility wording from the registry: \"* Histologically proven metastatic colorectal adenocarcinoma (on primary tumor and/or metastases) inoperable, well documented, i\". Sites: France. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06642844","url":"https://clinicaltrials.gov/study/NCT06642844"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06642844","phase":"3","setting":"Bevacizumab-based Chemotherapy Tailored to the Pharmacokinetics of Bevacizumab in First-line Treatment of Unresectable Metastatic Colorectal Cancer: a Randomized, Multicenter, Double-blind Phase 3 Study","sponsor":"University Hospital, Tours","enrolled":244,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06642844/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}