{"entity":{"id":"nct06671912","kind":"trial","name":"LoTam low-dose tamoxifen","aka":["Testing Low Dose Tamoxifen for Invasive Breast Cancer, LoTam Trial"],"tldr":"LoTam compares low-dose tamoxifen with usual hormone therapy after early breast cancer. The registry currently marks the study suspended.","summary":"LoTam compares low-dose tamoxifen with usual hormone therapy after early breast cancer. The registry currently marks the study suspended.\n\nInterventional study registered as NCT06671912, sponsored by Alliance for Clinical Trials in Oncology. Registry phase: 3. Registry enrollment is 1,556 participants (estimated). Registry status checked October 10, 2026: suspended. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.","asOf":"2026-10-10","links":[{"label":"ClinicalTrials.gov NCT06671912","url":"https://clinicaltrials.gov/study/NCT06671912"},{"label":"UCSF study listing and local availability","url":"https://clinicaltrials.ucsf.edu/trial/NCT06671912"}],"tags":["ucsf-breast-coverage","interventional"],"related":[],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["anastrozole","exemestane","letrozole","tamoxifen"],"companies":[],"institutions":["ucsf"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06671912","phase":"3","setting":"Postmenopausal hormone receptor-positive, HER2-negative early breast cancer","sponsor":"Alliance for Clinical Trials in Oncology","participation":[{"nct":"NCT06671912","source":"https://clinicaltrials.gov/study/NCT06671912","fetchedAt":"2026-10-10T20:54:19.990390Z","studySha256":"79bea5b2fabea025ffe42784c7eb230b92185be839ebd1ecb0706e49c3651ee1","overallStatus":"SUSPENDED","lastUpdatePosted":"2026-09-02","whyStopped":"Amending protocol to increase sample size","leadSponsor":"Alliance for Clinical Trials in Oncology","collaboratorCount":1,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":1556,"enrolmentType":"ESTIMATED","siteCount":732,"recruitingSiteCount":0,"countries":["Puerto Rico","United States"]}],"started":"2025-02-19","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06671912/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"drug":[{"id":"anastrozole","kind":"drug","name":"Anastrozole","route":"/drugs/anastrozole/"},{"id":"exemestane","kind":"drug","name":"Exemestane","route":"/drugs/exemestane/"},{"id":"letrozole","kind":"drug","name":"Letrozole (and other aromatase inhibitors)","route":"/drugs/letrozole/"},{"id":"tamoxifen","kind":"drug","name":"Tamoxifen","route":"/drugs/tamoxifen/"}],"institution":[{"id":"ucsf","kind":"institution","name":"UCSF Helen Diller Family Comprehensive Cancer Center","route":"/institutions/ucsf/"}]}}