{"entity":{"id":"nct06686771","kind":"trial","name":"Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer","aka":["CURB2"],"tldr":"A phase 3 trial in lung cancer, run by Canadian Cancer Trials Group, now recruiting.","summary":"Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT06686771 by Canadian Cancer Trials Group, with a registry enrolment figure of 320 participants, started 2025-12-16 and due to reach its primary completion in 2030-02-28. Interventions recorded: SBRT; First or second-line standard of care therapy. Conditions listed: Non-small Cell Lung Cancer. Primary outcome: Progression-free survival; Overall survival. Lung eligibility wording from the registry: \"* Metastatic disease (stage IV) detected on imaging and histologically and/or cytologically confirmed NSCLC as per the WHO Classification of Tumors and AJCC 8th Edition TNM Classification, without a driver mutation with an actionable first-line targeted therapy, for whom either ICI alone or combinat\". Sites: Canada, United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT06686771","url":"https://clinicaltrials.gov/study/NCT06686771"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":["cctg"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06686771","phase":"3","setting":"Consolidative Use of Radiotherapy to Block (CURB2) Oligoprogression In Patients With Metastatic Non-Small-Cell Lung Cancer","sponsor":"Canadian Cancer Trials Group","enrolled":320,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06686771/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"company":[{"id":"cctg","kind":"company","name":"Canadian Cancer Trials Group (CCTG)","route":"/companies/cctg/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}