{"entity":{"id":"nct06687941","kind":"trial","name":"A Study to Evaluate the Tolerability, Safety, and PK of AST-201 in Patients With GPC3-positive Advanced Solid Tumors","aka":[],"tldr":"A phase 1 trial of AST-201 run by Aptamer Sciences, Inc., now recruiting.","summary":"A Study to Evaluate the Tolerability, Safety, and PK of AST-201 in Patients With GPC3-positive Advanced Solid Tumors is a phase 1 interventional study registered as NCT06687941 by Aptamer Sciences, Inc., with 70 participants planned, started 2025-03-11. Conditions recorded: Neoplasms, Carcinoma, Hepatocellular, Carcinoma, Non-Small-Cell Lung and Liver Neoplasms. Interventions recorded: AST-201.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT06687941","url":"https://clinicaltrials.gov/study/NCT06687941"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","hcc","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["ast-201"],"companies":["aptamer-sciences"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06687941","phase":"1","setting":"A Multi-center, Open-label, Dose Escalation and Expansion, Phase 1 Study to Evaluate the Tolerability, Safety and Pharmacokinetics of AST-201 in Patients With GPC3-positive Advanced Solid Tumors","sponsor":"Aptamer Sciences, Inc.","enrolled":70,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06687941/","neighbours":{"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"ast-201","kind":"drug","name":"AST-201","route":"/drugs/ast-201/"}],"company":[{"id":"aptamer-sciences","kind":"company","name":"Aptamer Sciences","route":"/companies/aptamer-sciences/"}]}}