{"entity":{"id":"nct06714604","kind":"trial","name":"Standard or Prolonged Neoadjuvant Chemotherapy Before Surgery for BR/LAPC","aka":["ADVANTAGE"],"tldr":"A phase 3 trial in pancreatic cancer, run by Sahlgrenska University Hospital, now recruiting.","summary":"Standard or Prolonged Neoadjuvant Chemotherapy Before Surgery for BR/LAPC is a phase 3, randomised interventional study registered as NCT06714604 by Sahlgrenska University Hospital, with a registry enrolment figure of 432 participants, started 2023-10-18 and due to reach its primary completion in 2032-12-31. Interventions recorded: FOLFIRINOX or gemcitabine-nab-paclitaxel; FOLFIRINOX or gemcitabine-nab-paclitaxel. Conditions listed: Locally Advanced Pancreatic Adenocarcinoma; Borderline Resectable Pancreatic Carcinoma; Pancreas Cancer; Neoadjuvant Chemotherapy; Surgery; Pancreatectomy. Primary outcome: Overall survival of all BR/LAPC patients; Overall survival of all resected BR/LAPC patients. Pancreatic eligibility wording from the registry: \"* Borderline or locally advanced pancreatic adenocarcinoma at diagnosis according to National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines, version 1\". Sites: Sweden. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06714604","url":"https://clinicaltrials.gov/study/NCT06714604"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["borderline-resectable-pdac","resectable-pdac","locally-advanced-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06714604","phase":"3","setting":"Standard Versus Prolonged Neoadjuvant (Conversion) Chemotherapy to Prolong Survival of Patients With Borderline and Locally Advanced Pancreatic Cancer: a Phase III Randomized Controlled","sponsor":"Sahlgrenska University Hospital","enrolled":432,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06714604/","neighbours":{"cancer":[{"id":"borderline-resectable-pdac","kind":"cancer","name":"Borderline resectable pancreatic ductal adenocarcinoma","route":"/cancers/borderline-resectable-pdac/"},{"id":"locally-advanced-pdac","kind":"cancer","name":"Locally advanced unresectable pancreatic ductal adenocarcinoma","route":"/cancers/locally-advanced-pdac/"},{"id":"resectable-pdac","kind":"cancer","name":"Resectable pancreatic ductal adenocarcinoma","route":"/cancers/resectable-pdac/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}