{"entity":{"id":"nct06751394","kind":"trial","name":"Preoperative Chemoradiotherapy and Toripalimab in Locally Recurrent Rectal Cancer","aka":["TRACER"],"tldr":"A phase 2 trial of capecitabine, fOLFOX (5-FU, leucovorin, oxaliplatin) and fOLFIRI (5-FU, leucovorin, irinotecan) in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, not yet recruiting.","summary":"Preoperative Chemoradiotherapy and Toripalimab in Locally Recurrent Rectal Cancer is a phase 2, interventional study registered as NCT06751394 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 44 participants, started 2025-01-01 and due to reach its primary completion in 2028-12-31. Interventions recorded: PD-1 antibody (Toripalimab); Capecitabine; Oxaliplatin; Irinotecan; Radiation; surgery. Conditions listed: Recurrent Rectal Cancer. Primary outcome: Pathological complete response rate. Colorectal eligibility wording from the registry: \"Active inflammatory bowel disease or other colorectal diseases that lead to chronic diarrhea\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06751394","url":"https://clinicaltrials.gov/study/NCT06751394"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","imrt-igrt","platinum","topoisomerase-inhibitors"],"targets":[],"drugs":["capecitabine","folfox","folfiri"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06751394","phase":"2","setting":"Preoperative Treatment with Radiotherapy and Anti-PD1 for Resectable Recurrent Rectal Cancer (TRACER)","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","enrolled":44,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06751394/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"},{"id":"topoisomerase-inhibitors","kind":"technology","name":"Topoisomerase-I inhibitors (and ADC payloads)","route":"/technologies/topoisomerase-inhibitors/"}],"drug":[{"id":"capecitabine","kind":"drug","name":"Capecitabine","route":"/drugs/capecitabine/"},{"id":"folfiri","kind":"drug","name":"FOLFIRI (5-FU, leucovorin, irinotecan)","route":"/drugs/folfiri/"},{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}