{"entity":{"id":"nct06758830","kind":"trial","name":"Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.","aka":[],"tldr":"A phase 2/3 trial in colorectal cancer, run by National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos, now recruiting.","summary":"Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer. is a phase 2/3, randomised interventional study registered as NCT06758830 by National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos, with a registry enrolment figure of 400 participants, started 2025-01-06 and due to reach its primary completion in 2029-12-27. Interventions recorded: Radiation Therapy; Chemoradiotherapy; Consolidation Chemotherapy; Surgery; Part two; Adjuvant treatment. Conditions listed: Rectal Cancer; Total Neoadjuvant Treatment; Neoadjuvant Therapy; Radiotherapy; Chemotherapy; Organ Preservation; Radiotherapy Side Effect; Chemotherapy Side Effects; Chemoradiotherapy; Low Anterior Resection Syndrome; Quality of Life. Primary outcome: Postoperative complications; TNT toxicity; Mortality rate. Colorectal eligibility wording from the registry: \"* Pathologically confirmed rectal adenocarcinoma\". Sites: Lithuania. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06758830","url":"https://clinicaltrials.gov/study/NCT06758830"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06758830","phase":"2/3","setting":"Total Neoadjuvant Therapy for Rectal Cancer - a New Standard of Care?","sponsor":"National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos","enrolled":400,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06758830/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}