{"entity":{"id":"nct06760520","kind":"trial","name":"Short-course Radiotherapy Followed by CAPOX and Ivonescimab for Locally Advanced Rectal Cancer","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by The First Affiliated Hospital of Zhengzhou University, not yet recruiting.","summary":"Short-course Radiotherapy Followed by CAPOX and Ivonescimab for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT06760520 by The First Affiliated Hospital of Zhengzhou University, with a registry enrolment figure of 40 participants, started 2025-01-20 and due to reach its primary completion in 2027-12-20. Interventions recorded: Ivonescimab (SMT112 or AK112) Injection. Conditions listed: Locally Advanced Rectal Cancer. Primary outcome: Complete response rate (CR, pCR plus cCR ). Colorectal eligibility wording from the registry: \"* histologically or cytologically confirmed colorectal adenocarcinoma with non-distant metastasis\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06760520","url":"https://clinicaltrials.gov/study/NCT06760520"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06760520","phase":"2","setting":"A Single-arm, Prospective, Phase II Clinical Study of Short-course Radiotherapy Followed by CAPOX and Ivonescimab for Locally Advanced Low-middle Rectal Cancer with a High Risk of Recurrence","sponsor":"The First Affiliated Hospital of Zhengzhou University","enrolled":40,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06760520/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}