{"entity":{"id":"nct06767007","kind":"trial","name":"SBRT + PD-1 Antibody in Unresectable Locally Recurrent Rectal Cancer（SPARKLE）","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.","summary":"SBRT + PD-1 Antibody in Unresectable Locally Recurrent Rectal Cancer（SPARKLE） is a phase 2, interventional study registered as NCT06767007 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 31 participants, started 2025-01-06 and due to reach its primary completion in 2026-11-30. Interventions recorded: Stereotactic Body Radiation Therapy (SBRT); PD1; Chemotherapy. Conditions listed: Unresectable Locally Recurrent Rectal Cancer. Primary outcome: 1 year PFS. Colorectal eligibility wording from the registry: \"Patients with pMMR/MSS colorectal cancer;\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06767007","url":"https://clinicaltrials.gov/study/NCT06767007"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06767007","phase":"2","setting":"Evaluation of the Efficiency and Safety of Stereotactic Body Radiation Therapy Combined With PD-1 Antibody in the Treatment of Unresectable Locally Recurrent Rectal Cancer: A Prospective, Multicenter, Single-Arm, Open Label, Phase II Study","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","enrolled":31,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06767007/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}