{"entity":{"id":"nct06776757","kind":"trial","name":"Sintilimab in Combination with Cetuximab and Chemotherapy As First-line Treatment for RAS/BRAF Wild-type Advanced Colorectal Cancer","aka":[],"tldr":"A phase 1/2 trial in colorectal cancer, run by Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center, now recruiting.","summary":"Sintilimab in Combination with Cetuximab and Chemotherapy As First-line Treatment for RAS/BRAF Wild-type Advanced Colorectal Cancer is a phase 1/2, interventional study registered as NCT06776757 by Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center, with a registry enrolment figure of 30 participants, started 2023-12-25 and due to reach its primary completion in 2025-06-25. Interventions recorded: Sintilimab+Cetuximab+Chemotherapy (mFOLFOX6/FOLFIRI/CAPEOX/CAPIRI); Sintilimab+Cetuximab+Chemotherapy (mFOLFOX6/FOLFIRI/CAPEOX/CAPIRI). Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Objective Response Rate (ORR). Colorectal eligibility wording from the registry: \"Histologically or cytologically confirmed inoperable or recurrent metastatic colorectal cancer (AJCC 8th edition, Stage IV)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06776757","url":"https://clinicaltrials.gov/study/NCT06776757"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06776757","phase":"1/2","setting":"Sintilimab in Combination with Cetuximab and Chemotherapy As First-line Treatment for RAS/BRAF Wild-type Advanced Colorectal Cancer: an Open-label, Non-comparative, Phase 1b/2 Dose Escalation and Expansion Trial","sponsor":"Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center","enrolled":30,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06776757/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}