{"entity":{"id":"nct06778863","kind":"trial","name":"CLSP-1025 in p53 R175H solid tumors","aka":["A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation"],"tldr":"This early study tests CLSP-1025, which aims to bring immune cells to cancer cells displaying a particular mutated p53 fragment. Both the mutation and a matching immune-system marker are required.","summary":"This early study tests CLSP-1025, which aims to bring immune cells to cancer cells displaying a particular mutated p53 fragment. Both the mutation and a matching immune-system marker are required.\n\nInterventional study registered as NCT06778863, sponsored by Clasp Therapeutics, Inc.. Registry phase: 1. Registry enrollment is 90 participants (estimated). Registry status checked October 10, 2026: recruiting. UCSF lists this study as open to eligible people; local availability and overall registry status are separate. See the registry for full eligibility and current sites.","status":"recruiting","asOf":"2026-10-10","links":[{"label":"ClinicalTrials.gov NCT06778863","url":"https://clinicaltrials.gov/study/NCT06778863"},{"label":"UCSF study listing and local availability","url":"https://clinicaltrials.ucsf.edu/trial/NCT06778863"}],"tags":["ucsf-breast-coverage","interventional"],"related":[],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["ucsf"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06778863","phase":"1","setting":"Advanced solid tumors with p53 R175H and HLA-A*02:01","sponsor":"Clasp Therapeutics, Inc.","participation":[{"nct":"NCT06778863","source":"https://clinicaltrials.gov/study/NCT06778863","fetchedAt":"2026-10-10T20:54:18.246315Z","studySha256":"cdf259817fa5689e049b43401b1b48e5a524786f3b982831730a2a1446b352c7","overallStatus":"RECRUITING","lastUpdatePosted":"2026-02-13","leadSponsor":"Clasp Therapeutics, Inc.","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":90,"enrolmentType":"ESTIMATED","siteCount":21,"recruitingSiteCount":21,"countries":["United States"]}],"started":"2025-02-28","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06778863/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"institution":[{"id":"ucsf","kind":"institution","name":"UCSF Helen Diller Family Comprehensive Cancer Center","route":"/institutions/ucsf/"}]}}