{"entity":{"id":"nct06783491","kind":"trial","name":"Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon Cancer","aka":["FOXHIPECT4"],"tldr":"A phase 3 trial of mitomycin C and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Maimónides Biomedical Research Institute of Córdoba, now recruiting.","summary":"Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon Cancer is a phase 3, randomised interventional study registered as NCT06783491 by Maimónides Biomedical Research Institute of Córdoba, with a registry enrolment figure of 1083 participants, started 2026-05-26 and due to reach its primary completion in 2030-06-01. Interventions recorded: Mitomycin (MM); FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin); Cytoreductive surgery. Conditions listed: Locally Advanced Colorectal Cancer. Primary outcome: Disease-free survival absolute; Disease-free survival probability. Colorectal eligibility wording from the registry: \"* Adenocarcinoma of the colon, sigmoid colon and rectum-sigmoid junction that is cT4a/b according to the American Joint Committee on Cancer (AJCC) TNM eight edition\". Sites: Spain. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06783491","url":"https://clinicaltrials.gov/study/NCT06783491"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","hipec","platinum"],"targets":[],"drugs":["mitomycin","folfox"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06783491","phase":"3","setting":"Efficacy of the Use of Neoadjuvant With/Without Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Locally Advanced Colon Cancer: A Phase III Multi-arm, Randomized and Controlled Clinical Trial (FOXHIPECT4)","sponsor":"Maimónides Biomedical Research Institute of Córdoba","enrolled":1083,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06783491/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"hipec","kind":"technology","name":"HIPEC / PIPAC (intraperitoneal chemotherapy)","route":"/technologies/hipec/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"}],"drug":[{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"},{"id":"mitomycin","kind":"drug","name":"Mitomycin C","route":"/drugs/mitomycin/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}