{"entity":{"id":"nct06832917","kind":"trial","name":"Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC):","aka":["NeoCaCRT-III"],"tldr":"A phase 3 trial in colorectal cancer, run by Wan He, not yet recruiting.","summary":"Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III) is a phase 3, randomised interventional study registered as NCT06832917 by Wan He, with a registry enrolment figure of 238 participants, started 2025-03-31 and due to reach its primary completion in 2028-12-31. Interventions recorded: AK104 plus; Chemo only. Conditions listed: Rectal Cancer. Primary outcome: 3-year disease free survival (3-y DFS). Colorectal eligibility wording from the registry: \"Histopathology confirmed the diagnosis of rectal adenocarcinoma\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06832917","url":"https://clinicaltrials.gov/study/NCT06832917"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06832917","phase":"3","setting":"A Prospective Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Study to Explore the Efficacy and Safety of Cadonilimab Plus Chemotherapy After Short-course Radiotherapy in Locally Advanced Rectal Cancer","sponsor":"Wan He","enrolled":238,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06832917/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}