{"entity":{"id":"nct06843434","kind":"trial","name":"A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma","aka":[],"tldr":"A phase 2 trial of balstilimab and botensilimab in colorectal cancer, run by Memorial Sloan Kettering Cancer Center, now recruiting.","summary":"A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma is a phase 2, interventional study registered as NCT06843434 by Memorial Sloan Kettering Cancer Center, with a registry enrolment figure of 40 participants, started 2025-02-20 and due to reach its primary completion in 2028-02-20. Interventions recorded: Balstilimab; Botensilimab. Conditions listed: Microsatellite Stable Rectal Carcinoma; Locally Advanced Rectal Adenocarcinoma. Primary outcome: Best Overall Response Rate. Colorectal eligibility wording from the registry: \"* Histologically confirmed rectal adenocarcinoma\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06843434","url":"https://clinicaltrials.gov/study/NCT06843434"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","msi-high-colorectal"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["balstilimab","botensilimab"],"companies":["agenus"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06843434","phase":"2","setting":"A Phase II Study of Neoadjuvant Botensilimab and Balstilimab Immunotherapy for Mismatch Repair Proficient Rectal Adenocarcinoma","sponsor":"Memorial Sloan Kettering Cancer Center","enrolled":40,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06843434/","neighbours":{"cancer":[{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"balstilimab","kind":"drug","name":"Balstilimab","route":"/drugs/balstilimab/"},{"id":"botensilimab","kind":"drug","name":"Botensilimab","route":"/drugs/botensilimab/"}],"company":[{"id":"agenus","kind":"company","name":"Agenus","route":"/companies/agenus/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}