{"entity":{"id":"nct06843551","kind":"trial","name":"The Miami \"EMPIRE\" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation","aka":["EMPIRE"],"tldr":"A phase 2 trial of botensilimab and balstilimab in pancreatic cancer, run by Benjamin Spieler, now recruiting.","summary":"The Miami \"EMPIRE\" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation is a phase 2, interventional study registered as NCT06843551 by Benjamin Spieler, with a registry enrolment figure of 20 participants, started 2025-06-18 and due to reach its primary completion in 2030-08-01. Interventions recorded: Stereotactic Body Radiation Therapy; Botensilimab; Balstilimab. Conditions listed: Metastatic Pancreatic Ductal Adenocarcinoma; Metastatic Pancreatic Cancer. Primary outcome: Clinical Benefit Rate (CBR). Pancreatic eligibility wording from the registry: \"Histologically or cytologically confirmed diagnosis of pancreatic ductal adenocarcinoma\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06843551","url":"https://clinicaltrials.gov/study/NCT06843551"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["metastatic-pdac"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":["botensilimab","balstilimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06843551","phase":"2","setting":"A Phase 2 Single Arm Trial of Stereotactic Body Radiation Therapy Followed by Dual Immune Checkpoint Inhibition for Patients With Metastatic Pancreatic Ductal Adenocarcinoma - The Miami \"EMPIRE\" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation","sponsor":"Benjamin Spieler","enrolled":20,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06843551/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"drug":[{"id":"balstilimab","kind":"drug","name":"Balstilimab","route":"/drugs/balstilimab/"},{"id":"botensilimab","kind":"drug","name":"Botensilimab","route":"/drugs/botensilimab/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}