{"entity":{"id":"nct06846268","kind":"trial","name":"Neoadjuvant ADG126 and Pembrolizumab in Locally Advanced Colorectal Cancer","aka":[],"tldr":"A phase 2 trial of ADG126 and pembrolizumab in colorectal cancer, run by National University Hospital, Singapore, now recruiting.","summary":"Neoadjuvant ADG126 and Pembrolizumab in Locally Advanced Colorectal Cancer is a phase 2, interventional study registered as NCT06846268 by National University Hospital, Singapore, with a registry enrolment figure of 20 participants, started 2025-04-14 and due to reach its primary completion in 2027-12-31. Interventions recorded: ADG126; Pembrolizumab. Conditions listed: Locally Advanced Colorectal Cancer. Primary outcome: Rate of Major Pathologic Response (MPR). Colorectal eligibility wording from the registry: \"Histologically confirmed colorectal adenocarcinoma\". Sites: Singapore. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06846268","url":"https://clinicaltrials.gov/study/NCT06846268"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["adg126","pembrolizumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06846268","phase":"2","setting":"Phase II Trial of Neoadjuvant ADG126 and Pembrolizumab in Locally Advanced Colorectal Cancer","sponsor":"National University Hospital, Singapore","enrolled":20,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06846268/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"adg126","kind":"drug","name":"ADG126","route":"/drugs/adg126/"},{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}